Increased risk of myopathy w/ fibric acid derivatives (fibrates or gemfibrozil) & nicotinic acid. Ciclosporin, itraconazole, ketoconazole, erythromycin, clarithromycin, HIV-PIs, nefazodone, amiodarone, verapamil & grapefruit juice. Bleeding & increases in prothrombin time w/ coumarin anticoagulants. Increased plasma conc w/ erythromycin & other macrolides, itraconazole, ketoconazole, HIV-PIs & grapefruit juice. Reduced plasma conc w/ rifampicin. Risk for rhabdomyolysis & hepatitis w/ diltiazem. Reduction in 1st-pass metabolism due to inhibition of P-gp by esomeprazole.