Initially 10-20 mg once daily. Patient requiring large LDL-cholesterol reduction Initially 40 mg daily. May be adjusted at 4 wk intervals up to max of 80 mg daily.
Active liver disease. Assess liver function before starting treatment & subsequently; additional assessment after 3 mth, & before & after increasing the dose. Discontinue if creatine phosphokinase increased & myopathy is diagnosed. Renal impairment.
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