Astimol

Astimol

latanoprost + timolol

Manufacturer:

Aspen

Distributor:

Aspen
Concise Prescribing Info
Contents
Per mL Latanoprost 50 mcg, timolol maleate 5 mg
Indications/Uses
Reduction of IOP in patients w/ open angle glaucoma & ocular HTN who are insufficiently responsive to topical β-blockers or prostaglandin analogues.
Dosage/Direction for Use
1 drop in the affected eye(s) once daily.
Contraindications
Hypersensitivity. Reactive airways disease including bronchial asthma or history of bronchial asthma, severe COPD. Sinus bradycardia, sick sinus syndrome, sino-atrial block, 2nd or 3rd degree AV block not controlled w/ pacemaker, overt cardiac failure, cardiogenic shock.
Special Precautions
Systemic effects. May mask signs of acute hypoglycemia. May induce dryness of eyes. Choroidal detachment. May block systemic β-agonist effects. May change eye colour. Patients w/ CV diseases, 1st degree heart block; severe peripheral circulatory disturbance/disorders; mild/moderate COPD; labile diabetes; corneal disease. May produce +ve results in doping controls. Benzalkonium Cl content may cause punctate keratopathy &/or toxic ulcerative keratopathy which may cause eye irritation & known to discolour soft contact lenses. May affect ability to drive or operate machinery. Pregnancy & lactation. Childn.
Adverse Reactions
Increased iris pigmentation. Eye irritation.
Drug Interactions
Paradoxical elevations in IOP w/ other prostagladin analogues. Potentiated effect on IOP w/ oral β-adrenergic blocking agent. Hypotension or marked bradycardia w/ oral Ca channel blockers, β-adrenergic blocking agents, antiarrhythmics, digitalis glycosides, parasympathomimetics, guanethidine. Mydriasis w/ epinephrine. Potentiated hypertensive reaction to sudden w/drawal of clonidine. May increase hypoglycemic effect of antidiabetics. Potentiated systemic β-blockade eg, decreased heart rate, depression w/ CYP2D6 inhibitors.
MIMS Class
Antiglaucoma Preparations
ATC Classification
S01ED51 - timolol, combinations ; Belongs to the class of beta blocking agents. Used in the treatment of glaucoma.
Presentation/Packing
Form
Astimol ophth soln 50 mcg/5 mg/mL
Packing/Price
2.5 mL x 1's (P800/container)
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in