Solid organ transplantation Initially 10-15 mg/kg given in 2 divided doses 4-12 hr pre-op & continued for 1-2 wk post-op. Maintenance dose: 2-6 mg/kg/day.
Bone marrow transplantation Initially, 1st dose given via IV, starting on the day before transplantation. Oral therapy given at a dose of 12.5 mg/kg/day in 2 divided doses for 3-6 mth before gradually w/drawn.
RA Recommended dose: 2.5 mg/kg/day in 2 divided doses for the 1st 6 wk. May be increased subsequently to a max of 4 mg/kg/day.
Psoriasis Initially 2.5 mg/kg/day in 2 divided doses. May be increased to a max of 5 mg/kg/day if there is no improvement after 1 mth.
Atopic dermatitis 2.5-5 mg/kg/day in 2 divided doses for a max of 8 wk. May be increased to a max of 5 mg/kg/day if necessary after 2 wk.
Nephrotic syndrome To induce remission:
Adult 5 mg/kg/day.
Childn 6 mg/kg/day. To be given in 2 divided doses.
Mild renal impairment Max: 2.5 mg/kg/day.
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