Not to be given to patients w/ allergy to NSAIDs & asthma. Patients w/ ischemic heart disease, risk factors for heart disease, HTN, hyperlipidemia, diabetes, smoking & peripheral arterial disease. Use the lowest effective dose for the shortest duration of treatment in patients w/ CV risk. Discontinue use if appearance of skin rash & signs of hypersensitivity occurs. Potential GI (gastric & liver) & renal toxicities. Not to be used in patients w/ HTN whose BP is inadequately controlled. Contraindicated in patients w/ inflammatory bowel disease, moderate to severe heart failure & renal impairment (CrCl <30 mL/min). May affect ability to drive & use machines. Not recommended in women attempting to conceive. Contraindicated in pregnancy. Lactation.
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