Long-term treatment of circulatory disorders affecting the coronary arteries; prevention of attacks of angina; follow-up treatment of heart attack when symptoms of angina persist; high blood pressure in the lung circulation; treatment of severe weakness of heart muscle in combination w/ cardiac glycosides &/or diuretics.
View Angistad overdosage for action to be taken in the event of an overdose.
Administration
SR cap: May be taken with or without food: Swallow whole, do not chew/crush., Tab: Should be taken with food.
Contraindications
Hypersensitivity to nitrate compd; acute MI; impaired function of the left ventricle; shock; very low BP; diseases of the heart muscle w/ narrowing of the cavity of the heart; constrictive pericarditis; pericardial tamponade; aortic stenosis; marked anaemias; head trauma; cerebral haemorrhage; closed-angle glaucoma; hyperthyroidism; concomitant therapy w/ sildenafil citrate.
Nitrate headache. Fall in BP. Nausea, vomiting, transient skin disorders & allergic skin reactions.
Drug Interactions
May potentiate BP lowering effects w/ β blockers, Ca antagonists, other blood vessel dilating agents, neuroleptics or tricyclic antidepressants & alcohol; sildenafil. Raised in BP w/ dihydroergotamine. Weakening effect w/ non-steroidal antirheumatic drugs
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