Adult & childn Adjunct to antineoplastic therapy 5 mcg/kg daily starting not <24 hr after last dose of antineoplastic, may be given as single daily SC inj, as continuous IV/SC infusion or as daily IV infusion over 15-30 min. Continue until neutrophil count has stabilized w/in normal range, may take up to ≥14 days.
Bone marrow transplantation Initially 10 mcg/kg daily, adjusted according to response, may be given by IV infusion over 30 min or 4 hr, or by continuous IV/SC infusion over 24 hr.
Mobilization of peripheral blood progenitor cells 10 mcg/kg daily may be given as single daily SC inj or by continuous infusion for 4-7 days until leukapheresis. Dose is halved to 5 mcg/kg daily by SC inj if given after myelosuppressive chemotherapy.
Patients w/ congenital neutropenia Initially 12 mcg/kg daily given SC in single or divided doses & adjusted according to response.
Patients w/ idiopathic or cyclic neutropenia Initially 5 mcg/kg daily given SC in single or divided doses & adjusted according to response.
Patients w/ HIV infection & persistent neutropenia Initially 1 mcg/kg daily by SC inj, may be titrated up to max of 4 mcg/kg daily until a normal neutrophil count is achieved, then adjusted for maintenance according to response. Maintenance dose: 300 mcg daily on 1-7 days a wk.
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