Increased exposure & risk of hypotension w/ strong or moderate CYP3A4 inhibitors (PIs, azole antifungals, macrolides eg, erythromycin or clarithromycin, verapamil or diltiazem). Lower plasma conc w/ CYP3A4 inducers (rifampicin,
Hypericum perforatum). Increased BP lowering effects w/ grapefruit or grapefruit juice & medicinal products w/ antihypertensive properties. Risk of hyperkalemia w/ dantrolene infusion & verapamil. Increase tacrolimus blood levels. Increased risk of hypotension w/ clarithromycin. Increase trough conc of ciclosporin in renal transplant patients. Increased exposure w/ simvastatin.