Patients w/ renal artery stenosis; renal & hepatic impairment; hypotension; vol depletion or those on high-dose diuretic therapy; poor cardiac reserve, heart failure; severe aortic stenosis. Monitor serum K conc especially in the elderly & those w/ renal impairment & avoid concomitant use w/ K-sparing diuretics. Abrupt w/drawal. Discontinue use if ischemic pain occurs. Lactation.
Dizziness, flushing, headache, hypotension, peripheral edema, tachycardia & palpitations. Nausea & other GI disturbances, increased micturition frequency, lethargy, eye pain & mental depression; paradoxical increase in ischemic chest pain (start of treatment), excessive fall in BP leading to cerebral or myocardial ischemia or transient blindness. Rashes (including erythema multiforme), fever & abnormalities in liver function including cholestasis; myalgia, tremor; impotence.
C09DB06 - losartan and amlodipine ; Belongs to the class of angiotensin II receptor blockers (ARBs) and calcium channel blockers. Used in the treatment of cardiovascular disease.
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