Increased exposure w/ strong or moderate CYP3A4 inhibitors [PIs, azole antifungals, macrolides (eg, erythromycin or clarithromycin), verapamil or diltiazem]. May lower plasma conc w/ CYP3A4 inducers (eg, rifampicin,
Hypericum perforatum). Increased BP lowering effects w/ grapefruit or grapefruit juice & other medicinal products w/ antihypertensive properties. Risk of hyperkalemia w/ verapamil & IV dantrolene.