Essential HTN Adult 50-100 mg daily. May be gradually increased at interval of 2 wk up to 200 mg daily for difficult or severe cases. Continue treatment for at least 2 wk to ensure adequate response to therapy.
CHF Initially 100 mg daily as single or divided doses, but may range from 25-200 mg daily.
Severe heart failure in conjunction w/ standard therapy (NYHA class III-IV) Patient w/ serum K ≤5 mEq/L & serum creatinine ≤2.5 mg/dL Initially 25 mg once daily. May be increased to 50 mg once daily if tolerated, or reduced to 25 mg every other day if not tolerated.
Cirrhosis Adult w/ urinary Na+/K+ ratio >1 100 mg daily;
urinary Na+/K+ ratio <1 200-400 mg daily.
Nephrotic syndrome Adult 100-200 mg daily.
Edema in childn Initially 3 mg/kg daily in divided doses.
Diagnosis & treatment of primary hyperaldosteronism Adult Long test: 400 mg daily for 3-4 wk. Short test: 400 mg daily for 4 days.
Short-term pre-op treatment of primary hyperaldosteronism 100-400 mg daily in prep for surgery.
Hypokalemia/hypomagnesemia 25-100 mg daily.
Management of hirsutism 100-200 mg daily in divided doses.
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