IM/IV Adult & childn >12 yr 1-2 g inj once daily. Severe cases or infections caused by moderately sensitive organisms Increase to 4 g once daily. Infant & childn (3 wk-12 yr) 20-80 mg/kg daily. Weighing ≥50 kg ≥50 mg/kg as a slow IV infusion at least 30 min. Neonates ≤2 wk 20-50 mg/kg daily. Max: 50 mg/kg. Meningitis 100 mg/kg once daily. Max: 4 g daily. Duration of therapy: Neisseria meningitidis: 4 days; H. influenzae: 6 days; Strep pneumonia: 7 days; Susceptible enterobacteriaceae: 10-14 days. Gonorrhea250 mg IM single dose.Pre-op prophylaxis 1-2 g single dose 30-90 min prior to surgery. Preterminal renal failure (CrCl <10 mL/min)Max: 2 g daily.
Patients w/ history of hypersensitivity reactions to other drugs. Penicillin-sensitive patients. Discontinue use upon detection of sludge in the gallbladder by sonograms. Blood cell count should be check regularly during prolonged treatment. Hyperbilirubinemic neonates, especially prematures.