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Sultab

Sultab

sultamicillin

Manufacturer:

Zifam Pinnacle

Distributor:

Pinnacle House
Concise Prescribing Info
Contents
Sultamicillin
Indications/Uses
Infections caused by susceptible microorganisms eg, upper resp tract infections including sinusitis, otitis media & tonsillitis; lower resp tract infections including bacterial pneumonias & bronchitis; UTIs & pyelonephritis; skin & soft tissue infections; intra-abdominal & gonococcal infections. Patients requiring sulbactam/ampicillin therapy following initial treatment w/ sulbactam/ampicillin IM/IV.
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Dosage/Direction for Use
Adult including elderly 375-750 mg bd for 5-14 days. Uncomplicated gonorrhoea 2.25 g as single dose w/ concomitant probenecid 1 g. Any infection caused by hemolytic streptococci Treatment should be at least 10 days. Childn ≥30 kg Adult dose, <30 kg 25-50 mg/kg daily in 2 divided doses.
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Overdosage
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Administration
May be taken with or without food.
Contraindications
History of allergic reaction to penicillins.
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Special Precautions
Previous hypersensitivity to penicillin, cephalosporins & other allergens. Discontinue if an allergic reaction or superinfection w/ nonsusceptible organisms (eg, fungi) occur. Not to be used in infectious mononucleosis. Periodically check for organ system dysfunction (eg, renal, hepatic & hematopoietic system) during prolonged therapy. Clostridium difficile-associated diarrhea; drug-induced liver injury eg, cholestatic hepatitis & jaundice. False-positive glycosuria in urinalysis w/ Benedict & Fehling reagent, & Clinitest. Transient decrease in plasma conc of total conjugated estriol, estriol-glucuronide, conjugated estrone & estriol when ampicillin is administered to pregnant women. Not to be taken by patients w/ rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose galactose malabsorption. Pregnancy. Not recommended in lactation. Neonates.
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Adverse Reactions
Pseudomembranous colitis; anaphylactic shock & reaction, hypersensitivity; dizziness, somnolence, sedation, headache; dyspnoea; enterocolitis, melaena, diarrhoea, vomiting, abdominal pain, dyspepsia, nausea; angioedema, urticaria, dermatitis, rash, pruritus; fatigue, malaise. Ampicillin: Agranulocytosis, hemolytic anaemia, thrombocytopenic purpura, thrombocytopenia, leukopenia, neutropenia, eosinophilia, anaemia; convulsion; glossitis, stomatitis, tongue discolouration; cholestasis, hepatic cholestasis, bilirubinaemia, abnormal hepatic function, jaundice; toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme, exfoliative dermatitis; tubulointerstitial nephritis; abnormal platelet aggregation, increased ALT & AST.
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Drug Interactions
Decreased renal tubular secretion w/ probenecid. May produce additive alterations in platelet aggregation & coagulation tests w/ anticoagulants. Bacteriostatic drugs eg, chloramphenicol, erythromycin, sulfonamides & tetracyclines may interfere w/ bactericidal effect. Methotrexate toxicity & decreased methotrexate clearance. Leucovorin may need to be increased & administered for a longer period. Ampicillin: Increased incidence of rashes w/ allopurinol. Reduced OC effectiveness.
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Storage
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Description
View Sultab description for details of the chemical structure and excipients (inactive components).
MIMS Class
Penicillins
ATC Classification
J01CR04 - sultamicillin ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
Presentation/Packing
Form
Sultab FC tab 375 mg
Packing/Price
1 × 10's
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