ampicillin + sulbactam


Zifam Pinnacle


Pinnacle House
Concise Prescribing Info
Per 1.5 g vial Ampicillin 1,000 mg, sulbactam 500 mg
Infections caused by susceptible microorganisms eg, upper & lower resp tract infections including sinusitis, otitis media & epiglottitis; bacterial pneumonias; UTIs & pyelonephritis; intra-abdominal infections including peritonitis, cholecystitis, endometritis & pelvic cellulitis; bacterial septicemia; skin, soft tissue, bone, joint & gonococcal infections. May also be administered peri-operatively to reduce incidence of post-op wound infections in patients undergoing abdominal or pelvic surgery. Prophylaxis to reduce post-op sepsis.
Dosage/Direction for Use
IM/IV Adult 1.5-12 g daily in divided doses every 6-8 hr. Max: Sulbactam 4 g daily. Less severe infections may be treated every 12 hr. Mild infection 1.5-3 g daily. Moderate infection Up to 6 g daily. Severe infection Up to 12 g daily. Prophylaxis of surgical infection 1.5-3 g at anesth induction, may be repeated every 6-8 hr. Uncomplicated gonorrhoea 1.5 g as single dose w/ concomitant probenecid 1 g. Childn, infant & neonate 150 mg/kg daily every 6-8 hr. Neonate during 1st wk of life 75 mg/kg daily in divided doses every 12 hr.
History of allergic reaction to penicillins.
Special Precautions
Previous hypersensitivity to penicillins, cephalosporins & other allergens. Discontinue if an allergic reaction; severe skin reactions eg, toxic epidermal necrolysis, Stevens-Johnson syndrome, dermatitis exfoliative, erythema multiforme & acute generalized exanthematous pustulosis; or superinfection w/ nonsusceptible organisms occur. Not to be used in infectious mononucleosis. Periodically check for organ system dysfunction (eg, renal, hepatic & hematopoietic system) during extended therapy. Clostridium difficile-associated diarrhea; drug-induced liver injury eg, cholestatic hepatitis & jaundice. False-positive glycosuria in urinalysis w/ Benedict & Fehling reagent, & Clinitest. Pregnancy & lactation. Neonates (especially premature) & other infants.
Adverse Reactions
Anaemia, thrombocytopenia, eosinophilia; phlebitis; diarrhea; hyperbilirubinaemia; inj site pain; increased ALT, AST.
Drug Interactions
Decreased renal tubular secretion w/ probenecid. Ampicillin: Increased incidence of rashes w/ allopurinol. Substantial mutual inactivation w/ aminoglycosides. Altered platelet aggregation & coagulation tests w/ anticoagulants. Bacteriostatic drugs eg, chloramphenicol, erythromycin, sulfonamides & tetracyclines may interfere w/ the bactericidal effect of penicillins. Reduced effectiveness of estrogen-containing OCs. Decreased clearance of methotrexate. May need to increase leucovorin dose & administer for longer periods of time.
MIMS Class
ATC Classification
J01CR01 - ampicillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
Suljac powd for inj 1.5 g
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