Seegraf Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Warnings Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing Brand Resources

Concise Prescribing Info

Contents

Tacrolimus

Indications/Uses

Prophylaxis for organ rejection in patients receiving allogenic kidney or liver transplant, used along w/ adrenal corticosteroids.

Click to view Seegraf detailed prescribing information

Dosage/Direction for Use

Adult patients in renal transplantation Recommended initial oral dose: 0.2 mg/kg/day in 2 divided doses 12 hrly. Whole blood conc during mth 1-3 should be maintained between 7-20 ng/mL & 5-15 ng/mL during the 4th mth & onwards. 1st dose should be administered after the renal function has recovered (eg, serum creatinine <4 mg/dL). Patients in liver transplantation 0.1-0.15 mg/kg/day administered in 2 divided doses 12 hrly. Most patients are stable when trough whole blood conc are maintained between 5-20 ng/mL.

Click to view Seegraf detailed prescribing information

Overdosage

View Seegraf overdosage for action to be taken in the event of an overdose.

Administration

Should be taken on an empty stomach: Take at least 1 hr before or 2-3 hr after meals.

Contraindications

Hypersensitivity.

Click to view Seegraf detailed prescribing information

Warnings

For additional cautionary notes to warn of the potential risk of using the medicine... Click to view Seegraf detailed prescribing information

Special Precautions

Increased susceptibility to infection & possible development of lymphoma may result from immunosuppression. Increased risk of developing lymphomas & other malignancies particularly of the skin. Oversuppression of the immune system w/ increase susceptibility to infection. Caution in treatment w/ combined immunosuppressives. HTN. Pregnancy & lactation. Childn.

Click to view Seegraf detailed prescribing information

Use In Pregnancy & Lactation

Click to view Seegraf detailed prescribing information

Adverse Reactions

Tremor, headache, diarrhea, hypertension, nausea & renal dysfunction.

Click to view Seegraf detailed prescribing information

Drug Interactions

Potential additive or synergistic renal function impairment w/ aminoglycosides, amphotericin B and cisplatin. Additive/synergistic nephrotoxicity w/ cyclosporine. Increased Seegraf levels w/ diltiazem, nicardipine, nifedipine, verapamil, clotrimazole, fluconazole, itraconazole, ketoconazole, clarithromycin, erythromycin, troleandomycin, cisapride, metoclopramide, bromocriptine, cimetidine, cyclosporine, danazol, ethinyl estradiol, methylprednisolone, omeprazole, protease inhibitors, nefazodone. Reduced Seegraf levels w/ carbamazepine, phenobarb, phenytoin, rifabutin, rifampin & St. John's wort.

Click to view Seegraf detailed prescribing information

Storage

View Seegraf storage conditions for details to ensure optimal shelf-life.

Description

View Seegraf description for details of the chemical structure and excipients (inactive components).

Action

View Seegraf mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Immunosuppressants

ATC Classification

L04AD02 - tacrolimus ; Belongs to the class of calcineurin inhibitors. Used as immunosuppressants.

Regulatory Classification

POM

Presentation/Packing

Form

Seegraf cap 0.5 mg

Packing/Price

6 × 10's

Form

Seegraf cap 1 mg

Packing/Price

6 × 10's

Seegraf

tacrolimus

Manufacturer:

Micro Labs

Distributor:

Zizawa Healthcare