There is insufficient experience of acute toxicity with cefoperazone sodium and sulbactam sodium in humans. Overdose with medicinal product is supposed to result in reactions which are adverse drug reactions, reported for the product, with higher intensity. It must be taken note of the fact, that high concentrations in central nervous system of beta-lactam antibiotics may provoke neurological effects, including seizures. As both cefoperazone and sulbactam are removed from circulation through dialysis, these procedures may quicken medicinal product elimination from the organism, if overdose occurs in patients with impaired renal function.