Ruvastin Drug Interactions

Erythromycin: Co-administration of erythromycin with rosuvastatin decreased AUC and C_max of rosuvastatin.
Itraconazole: Itraconazole increases the AUC of rosuvastatin.
Fluconazole: Co-administration of fluconazole with rosuvastatin increases the AUC of rosuvastatin.
Warfarin: The pharmacokinetics of warfarin is not significantly affected following co-administration with rosuvastatin.
Cyclosporin: Co-administration of rosuvastatin with cyclosporin resulted in no significant changes in cyclosporin plasma concentration.
Gemfibrozil: Concomitant use of rosuvastatin and gemfibrozil resulted in a 2-fold increase in C_max and AUC_(0-t).
Antacid: The simultaneous dosing of rosuvastatin with an antacid suspension containing aluminium and magnesium hydroxide resulted in a decrease in rosuvastatin plasma concentration of approximately 50%.
There are no clinically significant interactions with an oral contraceptive, digoxin, fenofibrate, antihypertensive agents, antidiabetic agents and hormone replacement therapy.