Palonosetron is used to prevent nausea and vomiting associated with cancer chemotherapy.
This medicine may also be used to prevent nausea and vomiting that may occur after surgery.
Palonosetron injection is to be given intravenously (into the vein). It is delivered directly into the bloodstream via the blood vessel.
Your doctor or nurse will administer the injection for you.
Ensure that you keep all appointments with your doctor so that you do not miss any doses. Your doctor also needs to regularly monitor your response to Palonosetron.
If you miss an appointment or miss an injection, alert your doctor or nurse. A replacement appointment or injection should be given as soon as possible.
Inform your doctor if you have the following conditions:
- history of constipation
- bowel problems
- heart problems e.g. abnormal heart rhythm
- electrolyte imbalance (imbalance of essential minerals in the body)
Let your doctor know if you are pregnant or breastfeeding.
Palonosetron may cause dizziness, drowsiness, or tiredness. If affected, do not drive or take part in any activity in which you need to be alert.
Other side effects may include any of the following: headache, eye irritation, constipation, diarrhoea, stomach pain or wind, joint pain, difficulty sleeping, and pain, discomfort or burning sensation at the injection site.
Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
- signs of allergic reactions e.g. rashes, breathlessness, swelling of the face, eyes, or mouth
- chest pain, shortness of breath, irregular or abnormal heartbeat
- confusion, flushing, sweating, fever, muscle twitching and jerking, stiff muscles, fits or seizures
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Inform your doctor and pharmacist if you are taking any of these medicines:
- other medicines to prevent nausea and vomiting in cancer chemotherapy e.g. ondansetron, granisetron, dolasetron
- medicines used to treat depression e.g. fluoxetine, sertraline, citalopram, venlafaxine, mirtazapine
- strong painkillers e.g. fentanyl, tramadol
- lithium (medicine for mood disorders)
This list does not include all medicines that may interact with Palonosetron.
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements, and medicines that you buy without a prescription.
Avoid alcohol.
Store in a cool, dry place away from the reach of children.
Protect from light. Do not freeze.
Medicines must not be used past the expiry date.
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