Nitrendipine: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Myanmar prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Hypertension

Adult: 20 mg daily as a single dose or in 2 divided doses, may be increased to 20 mg bid as necessary to control resistant HTN.
Elderly: Initially, 10 mg daily.

Hepatic Impairment

Initially, 5-10 mg once daily.

Administration

Should be taken with food.

Contraindications

Unstable angina pectoris, use w/in 1 mth of MI, cardiogenic shock.

Special Precautions

Patients w/ severe aortic stenosis, poor cardiac reserve, heart failure. Hepatic impairment. Elderly. Pregnancy and lactation.

Adverse Reactions

Headache, fatigue, flushing, palpitations, dizziness, peripheral oedema, polyuria, elevated LFTs.

Drug Interactions

Increased serum levels w/ cimetidine. Decreased serum levels w/ bile acids (e.g. ursodeoxycholic acid).

Food Interaction

May increase serum concentration w/ grapefruit juice.

Action

Description: Nitrendipine relaxes coronary vascular smooth muscles by inhibiting Ca ions. It lowers BP primarily by arteriolar dilation.
Pharmacokinetics:
Absorption: Well absorbed from the GI tract. Absolute bioavailability: 10-30%. Time to peak plasma concentration: 1-3 hr.
Distribution: Plasma protein binding: Approx 98%.
Metabolism: Metabolised in the liver. Undergoes extensive first-pass metabolism.
Excretion: Via urine and faeces (as inactive metabolites, <0.1% as unchanged drug). Terminal elimination half-life: Approx 10-22 hr.

Storage

Protect from light.

MIMS Class

Calcium Antagonists

References

Anon. Nitrendipine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 17/12/2013.

Buckingham R (ed). Nitrendipine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 17/12/2013.

Preston CL (ed). Calcium-channel blockers + Grapefruit juice. Stockley’s Drug Interactions [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 12/05/2014.

Preston CL (ed). Calcium-channel blockers + H2-receptor antagonists. Stockley’s Drug Interactions [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 12/05/2014.

Preston CL (ed). Calcium-channel blockers; Nitrendipine + Bile acids. Stockley’s Drug Interactions [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 12/05/2014.

Wickersham RM. Nitrendipine. Facts and Comparisons [online]. St. Louis, MO. Wolters Kluwer Clinical Drug Information, Inc. https://www.wolterskluwercdi.com/facts-comparisons-online/. Accessed 17/12/2013.

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