Pregabalin is not generally considered effective in the treatment of absence seizures.
Methylcobalamin is known to be substantially excreted by the kidney, and the risk of methylcobalamin accumulation and lactic acidosis increases with the degree of impairment of renal function. Thus, patients with serum creatinine levels above the upper limit of normal for their age should not receive methylcobalamin.
Effects on the Ability to Drive or Operate Machinery: Special care should be taken by patients driving, operating machinery or performing any hazardous tasks.