Letermovir is used to prevent infections cause by a virus called cytomegalovirus (CMV) in patients who recently had a bone marrow transplant.
Letermovir injection is to be given intravenously (into the vein). It is delivered directly into the bloodstream via the blood vessel.
Your doctor or nurse will administer the injection for you.
Ensure that you keep all appointments with your doctor so that you do not miss any doses. Your doctor also needs to regularly monitor your response to Letermovir.
If you miss an appointment or miss an injection, alert your doctor or nurse. A replacement appointment or injection should be given as soon as possible.
Do not use Letermovir if you ever had an allergic reaction (e.g. rashes, breathlessness, swollen eyes) to this medicine or any of its ingredients.
Do not use this medicine with certain herbal medicine, medicines used to treat high cholesterol levels, mood disorder, migraine, or blood clots. Please see the section “Can I take this with other medicines?” below for more information.
Inform your doctor if you have severe liver disease or combination of liver and kidney disease.
Let your doctor know if you are pregnant or breastfeeding.
For as long as you are using Letermovir, you may need to have regular blood tests to check your body’s response to the medicine. Your doctor will advise you about how often you need to have blood tests.
Letermovir may cause dizziness with spinning sensation or tiredness. If affected, do not drive or take part in any activity in which you need to be alert.
Other side effects include any of the following: headache, cough, nausea, diarrhoea, vomiting, stomach pain, swelling in the ankles, feet or legs.
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Do not use Letermovir with the following medicines:
- cholesterol-lowering medicines e.g. atorvastatin, simvastatin, rosuvastatin, pitavastatin
- medicines for migraine e.g. ergotamine, dihydroergotamine
- medicine for mood disorders e.g. pimozide
- blood-thinning medicine e.g. dabigatran
- St. John’s wort (herbal medicine)
Inform your doctor and pharmacist if you are taking or using any of these medicines:
- strong painkillers e.g. fentanyl, alfentanil
- medicines for heart disease e.g. amiodarone
- medicines used in organ transplant or certain immune disorders e.g. tacrolimus, sirolimus, ciclosporin
- medicines for diabetes e.g. glyburide
- certain antibiotics e.g. nafcillin
- medicines for epilepsy (fits or seizure) e.g. phenytoin, phenobarbital
- medicines for TB (lung infection known as tuberculosis) e.g. rifampicin, rifabutin
- other medicine for mood disorder e.g. thioridazine
- gastric medicines e.g. omeprazole, pantoprazole
- medicine for fungal infections e.g. voriconazole
- medicines for HIV infection e.g. efavirenz, etravirine
- medicine for high blood pressure in the vessels in the lungs e.g. bosentan
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
Avoid alcohol.
Avoid St. John’s wort.
Store in a cool, dry place away from the reach of children. Protect from light.
Medicines must not be used past the expiry date.
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