Isolated cases of overdose have been reported. The maximum dose taken was approximately 48,000 mg.
Symptoms: Electrolyte and fluid balance conditions: Hyponatraemia.
Eye disorders: Diplopia, miosis, blurred vision.
Gastrointestinal disorders: Nausea, vomiting, hyperkinesia.
General disorders and administration site conditions: Fatigue.
Investigations: Respiratory rate depression, QTc prolongation.
Nervous system disorders: Drowsiness and somnolence, dizziness, ataxia and nystagmus, tremor, disturbances in coordination (coordination abnormal), convulsion, headache, coma, loss of consciousness, dyskinesia.
Psychiatric disorders: Aggression, agitation, confusional state.
Vascular disorders: Hypotension.
Respiratory, thoracic and mediastinal disorders: Dyspnoea.
Treatment: There is no specific antidote. Symptomatic and supportive treatment should be administered as appropriate. Removal of the medicinal product by gastric lavage and/or inactivation by administering activated charcoal should be considered.