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The clinical studies have demonstrated the absence of interaction with the drugs such as: warfarin, tolbutamide, aspirin (acetylsalicylic acid), chlorpromazine, indomethacin.
General: It is recommended to initiate therapy with one capsule at night for the first 2 to 4 weeks as use of the drug can produce an acceleration of the intestinal transit time initially.
It is recommended to continue treatment for at least 6 months. The clinical studies have demonstrated that the drug can be used for 2 years without serious adverse effects.
As with any other long term therapy, it is recommended to monitor laboratory parameters, including hepatic enzymes, every 6 months.
Combined use with laxatives is contraindicated.
