Pharmacology: Ipralin hydrofluoroalkane (HFA) inhaler contains ipratropium bromide and salbutamol. lpratropium bromide is an anticholinergic (parasympatholytic) agent, which inhibit vagally-mediated reflexes by antagonizing the action of acetylcholine, released from the vagus nerve. Anticholinergics prevent the increase in intracellular concentration of cyclic guanosine monophosphate (cGMP), which are caused by the interaction of acetylcholine with the muscarinic receptors on bronchial smooth muscle. This opens bronchi and causes bronchodilation. Salbutamol is a selective β2-adrenoceptor agonist. At therapeutic doses, it acts on the β2-adrenoceptors of bronchial smooth muscle, with little or no action on the β1-adrenoceptors of cardiac muscle. Salbutamol provides short acting (4-6 hrs) bronchodilatation with a fast onset (within 5 min) in reversible airways obstruction.
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