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Carcinogenicity & Mutagenicity: In carcinogenicity tests of Fugacar in mice and rats, no carcinogenic effects were seen at doses as high as 40 mg/kg given daily for >2 years. Dominant lethal mutation tests in mice showed no mutagenicity at single doses as high as 640 mg/kg. Neither the spermatocyte test, the F1 translocation test, nor the Ames test indicated mutagenic properties.
Use in children: Mebendazole has not been extensively studied in children <2 years; therefore, in the treatment of children <2 years the relative benefit/risk should be considered.
