Adalimumab treatment as monotherapy and with concomitant methotrexate has been studied in rheumatoid arthritis, polyarticular juvenile idiopathic arthritis and psoriatic arthritis patients. Adalimumab when given with methotrexate results in lower antibody formation, decreased clearance and increased efficacy of Adalimumab in comparison to Adalimumab monotherapy treatment. Combinations of Adalimumab with Anakinra, and Adalimumab with Abatacept are not recommended.