Esomeprazole is a weak inducer of the cytochrome P450 enzyme system and the possibility exists that there may be interactions with drugs metabolised by this system. No interaction has been found with diazepam, oral contraceptives, prednisone, propranolol, phenytoin and theophylline. However, patients receiving concomitant warfarin should be monitored as minor reduction of the concentration of warfarin may occur.
No significant interaction with concomitantly administered antacids has been found.