Zavedos Caution For Usage

Special precautions for disposal and other handling: Preparation of the Solution: Idarubicin hydrochloride in a 5-, 10-, or 20-mg vial must be dissolved in 5, 10, and 20 mL, respectively, of Water for Injections only. The resulting solution is hypotonic and the recommended administration procedure described as follows must be followed.
The vial contents are under a negative pressure to minimise aerosol formation during reconstitution therefore particular care should be taken when the needle is inserted. Inhalation of any aerosol produced during reconstitution must be avoided.
Protective Measures: The following protective recommendations are given due to the toxic nature of this substance: Personnel should be trained in good technique for reconstitution and handling.
Pregnant staff should be excluded from working with this drug.
Personnel handling idarubicin hydrochloride should wear protective clothing: goggles, gowns and disposable gloves and masks.
A designated area should be defined for reconstitution (preferably under a laminar flow system). The work surface should be protected by disposable, plastic-backed, absorbent paper.
All items used for reconstitution, administration or cleaning, including gloves, should be placed in high-risk waste disposal bags for high temperature incineration.
Spillage or leakage should be treated with dilute sodium hypochlorite (1% available chlorine) solution, preferably by soaking, and then water.
All cleaning materials should be disposed of as indicated previously.
Accidental contact with the skin or eyes should be treated immediately by copious lavage with water, or soap and water, or sodium bicarbonate solution, medical attention should be sought.
In case of contact with the eye(s), hold back the eyelid(s) and flush the affected eye(s) with copious amounts of water for at least 15 minutes. Then seek medical evaluation by a physician.
Always wash hands after removing gloves.
Discard any unused solution.
Incompatibilities: Idarubicin hydrochloride should not be mixed with other drugs. Contact with any solution of an alkaline pH should be avoided as it will result in degradation of the drug. Idarubicin hydrochloride should not be mixed with heparin due to chemical incompatibility that may lead to precipitation.