Zanidip Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Lercanidipine HCl

Indications/Uses

Mild to moderate essential HTN.

Click to view Zanidip detailed prescribing information

Dosage/Direction for Use

10 mg once daily, may be increased to 20 mg daily.

Click to view Zanidip detailed prescribing information

Overdosage

View Zanidip overdosage for action to be taken in the event of an overdose.

Administration

Should be taken on an empty stomach: Take at least 15 min before meals.

Contraindications

Hypersensitivity. Left ventricular outflow tract obstruction, untreated congestive cardiac failure, unstable angina pectoris or recent MI (w/in 1 mth). Co-administration w/ strong CYP3A4 inhibitors, cyclosporin, grapefruit or grapefruit juice. Severe hepatic or renal impairment; patients undergoing dialysis.

Click to view Zanidip detailed prescribing information

Special Precautions

Sick sinus syndrome w/o pacemaker; left ventricular dysfunction; ischaemic heart disease; peritoneal dialysis. Galactose intolerance, total lactase deficiency or glucose-galactose malabsorption. Avoid use w/ alcohol. Concomitant use w/ CYP3A4 inducers ie, anticonvulsants (eg, phenytoin, carbamazepine), rifampicin. May affect ability to drive & use machines. Not recommended in severe hepatic or renal impairment (GFR <30 mL/min). Mild to moderate renal or hepatic impairment. May affect fertility. Not recommended in women of childbearing potential & during pregnancy. Not to be used during lactation. Not recommended in childn <18 yr. Elderly.

Click to view Zanidip detailed prescribing information

Use In Pregnancy & Lactation

Click to view Zanidip detailed prescribing information

Adverse Reactions

Headache; tachycardia, palpitations; flushing; peripheral oedema.

Click to view Zanidip detailed prescribing information

Drug Interactions

Avoid co-administration w/ CYP3A4 inhibitors eg, ketoconazole, itraconazole, ritonavir, erythromycin, troleandomycin, clarithromycin. Increased cyclosporin, simvastatin AUC. Increased hypotensive effect w/ grapefruit or grapefruit juice, high-dose cimetidine, other BP-affecting drugs eg, α-blockers, TCAs, neuroleptics. Reduced antihypertensive effect w/ CYP3A4 inducers ie, anticonvulsants (eg, phenytoin, phenobarb, carbamazepine), rifampicin. Potentiated effect w/ alcohol. Increased absorption w/ midazolam. Reduced bioavailability w/ metoprolol. Increased digoxin C_max. Reduced hypotensive effect w/ corticosteroids. Caution w/ other CYP3A4 substrates ie, terfenadine, astemizole, class III antiarrhythmics eg, amiodarone, quinidine, sotalol.

Click to view Zanidip detailed prescribing information

Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Zanidip detailed prescribing information

Storage

View Zanidip storage conditions for details to ensure optimal shelf-life.

Description

View Zanidip description for details of the chemical structure and excipients (inactive components).

Action

View Zanidip mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Calcium Antagonists

ATC Classification

C08CA13 - lercanidipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.

Regulatory Classification

Presentation/Packing

Form

Zanidip FC tab 10 mg

Packing/Price

28's

Form

Zanidip FC tab 20 mg

Packing/Price

28's

Zanidip

lercanidipine

Manufacturer:

Abbott

Distributor:

Zuellig Pharma