Xevolac Dosage/Direction for Use

Parenteral administration: The starting dose should be 10mg with subsequent doses of 10-30mg four to six hourly as required. The lowest effective dose should be used. The total daily dose of 90mg for the nonelderly and 60mg for the elderly should not be exceeded. Maximum duration of parenteral treatment is 2 days for all age groups. In patients who have received parenteral ketorolac and are converted to oral tablets, the total combined daily dose of all forms of ketorolac should not exceed 90mg for non-elderly and 60mg for the elderly. Maximum duration of treatment for the oral formulation is 7 days.
Xevolac solution for injection are for administration by intramuscular or bolus intravenous injection. Bolus intravenous doses should be given over no less than 15 seconds. Xevolac solution for injection should not be used for epidural or spinal administration. Dosage should be adjusted according to the severity of the pain and the patient response.
Special dosage instructions: Elderly patients: For patients over 65 years, the lower end of the dosage range is recommended. A total daily dose of 60mg should not be exceeded.
Children: Safety and efficacy in children have not been established. Therefore, Xevolac solution for injection is contraindicated for use in children under 16 years of age.
Renal impairment: Since ketorolac trometamol and its metabolites are excreted primarily by the kidney, Xevolac solution for injection is contraindicated in moderate to severe renal impairment (serum creatinine>160mmol/l): patients with lesser renal impairment should receive a reduced dose (not exceeding 60 mg per day IV or IM), and their renal status should be closely monitored. After assessing the risk/benefit ratio in each individual patient, the lowest effective dose for the shortest possible duration should be used.
Mode of Administration: Intramuscular or bolus intravenous.