Urofollitropin is used to treat female infertility. It helps induce ovulation in adult women who are unable to become pregnant because their ovaries cannot produce eggs, including polycystic ovarian disease (a hormonal disorder that may cause irregular menstrual periods, acne, or unwanted hair growth), or to stimulate the maturation of follicles in the ovaries for assisted reproduction programmes.
Urofollitropin is to be injected subcutaneously (into the fatty layer under the skin) or intramuscularly (into the muscle).
Your doctor or nurse will administer the injection for you if this medicine is to be given intramuscularly.
If you or your caregiver had been given the proper training on the preparation and injection techniques of this medicine, you or your caregiver may do the subcutaneous administration.
Use Urofollitropin exactly as directed by your doctor or according to the instructions on the label. Do not administer more or less than instructed by your doctor.
Remember to rotate the injection sites. Do not inject into the same area all the time. New injection sites should be at least 1.5 inches away from the previous injection site. Do not inject near the navel (belly button).
The dose, route, and schedule of administration of Urofollitropin will be decided by your doctor. Your doctor will advise you on the course of the treatment depending on your condition and response to the medication.
Ensure that you keep all appointments with your doctor so that you do not miss any doses. Your doctor also needs to regularly monitor your response to Urofollitropin.
If you are receiving your dose intramuscularly and you miss an appointment or miss an injection, alert your doctor or nurse. A replacement appointment or injection should be given as soon as possible.
If you are receiving your dose subcutaneously, administer the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.
DO NOT double a dose under any circumstances.
If you often forget to administer your medicine, let your doctor and pharmacist know.
Alert your doctor if you have the following conditions:
- tumours of the pituitary gland or hypothalamus
- cancer of the ovaries, womb, or breasts
- unexplained bleeding from the vagina
- malformation of sexual organs which makes pregnancy unsuitable
- fibroids (muscular tumours) of your womb which makes pregnancy unsuitable
- cyst on your ovaries or enlarged ovaries not due to polycystic ovarian disease
- primary ovarian failure (a condition wherein a woman's ovaries stop working normally before the age 40)
as Urofollitropin may not be suitable for you.
Do not use this medicine if you are pregnant. If you become pregnant while being treated with this medicine, alert your doctor immediately. Urofollitropin may cause harm to your unborn child.
Do not breastfeed while you are being treated with Urofollitropin.
Inform your doctor if you have the following conditions:
- risk factors for thromboembolism (blockage of a blood vessel by a blood clot) e.g. severe obesity, personal or family history of blood clots, thrombophilia (a condition that increases your tendency to form blood clots)
- liver disease
- kidney disease
Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
- Routine tests (e.g. ultrasound, estrogen levels) may be done while you are being treated with this medicine. Your doctor will advise you about how often you need to have these tests.
- Regular monitoring of signs and symptoms of high levels of activity in the ovaries, and formation of blood clots may also be needed.
- Your doctor will inform you when it is more suitable to have sexual contact or when to refrain from intercourse or use certain “barrier” contraceptive methods (e.g. condoms).
- Regular monitoring of your condition may be needed while you are being treated with Urofollitropin as this medicine may increase your risk of an ectopic pregnancy (a pregnancy in which the fetus develops outside of the womb), multiple births, pregnancy loss, or birth defects in your unborn baby.
Urofollitropin may cause any of the following side effects: headache, dizziness, nausea, constipation, hot flushes, tiredness, changes in mood, and breast pain or enlargement.
Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
- abdominal pain or swelling, difficulty breathing, decreased urination, sudden weight gain, nausea or diarrhoea as these are possible symptoms of ovarian hyperstimulation syndrome (OHSS)
- signs of blood clots such as pain, swelling and tenderness in your leg accompanied by redness and warmth, shortness of breath, or sudden chest pain
- rashes, breathlessness, swollen eyes, mouth, or throat
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Inform your doctor and pharmacist if you are taking clomifene (other medicine for female infertility).
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements, and medicines that you buy without a prescription.
Avoid alcohol.
Store in a cool, dry place or in the refrigerator, between 2-8°C.
Do not freeze Urofollitropin otherwise it will no longer be effective and should not be used.
Protect from light.
Medicines must not be used past the expiry date.
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