Adult including elderly 200 or 400 mg daily. Min effective dose: Not to exceed 6.5 mg/kg daily. Patient able to receive 400 mg daily Initially 400 mg daily in divided doses, may be reduced to 200 mg if no further improvement or increased to 400 mg daily as maintenance if response lessens. Childn Min effective dose: Not to exceed 6.5 mg/kg daily.
Sensitivity to quinine. Discontinue use if pigmentary abnormality, visual field defect, unexplainable abnormalities by difficulty in accommodation or presence of corneal opacities, visual disturbances including abnormal colour vision develops; anaemia, aplastic anaemia, agranulocytosis, decreased WBC & thrombocytopenia occur. Increased risk of retinopathy & hypoglycaemia. Severe GI, neurological or blood disorders; porphyria cutanea tarda, psoriasis. Perform ophth exam prior to initiation & repeat at least every 12 mth. Periodic exam of skeletal muscle function & tendon reflexes in long-term use. Concomitant use w/ drugs causing adverse ocular or skin reactions. G6PD deficiency. Galactose intolerance, Lapp-lactase deficiency or glucose-galactose malabsorption. May affect ability to drive or operate machinery. Hepatic or renal disease. Not to be used during pregnancy. Lactation. Small childn.
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