Talazoparib is used to treat a certain cancer of the breast known as HER2- negative breast cancer in individuals with changes in their genes called BRCA.
It is used for those whose tumour has spread to other parts of the body.
Take Talazoparib exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.
You may take this medicine with or without food. Try to take it at the same time each day.
Talazoparib is available as a capsule, swallow the capsule whole with a glass of water. Do not chew or crush the capsules.
If you vomit after taking Talazoparib, do not repeat the dose. Take the next dose at your normal scheduled time.
If you experience certain side effects, inform your doctor immediately. Your doctor may lower your dose or stop your treatment, either temporarily or permanently.
If you miss a dose, do not take the missed dose. Take your next usual dose at its scheduled time.
DO NOT double a dose under any circumstances.
If you often forget to take your medicine, let your doctor and pharmacist know.
Do not take Talazoparib if you are pregnant. If you become pregnant while on Talazoparib therapy, alert your doctor immediately. This medicine may cause harm to your unborn child.
It is important that you do not get pregnant while taking Talazoparib. Both men and women must use proven birth control methods during Talazoparib therapy and for at least 7 months (in women) or 4 months (in men) after stopping the treatment. You may wish to discuss other reliable methods of birth control with your doctor.
Do not breastfeed while you are being treated with this medicine and for at least 1 month after stopping the treatment.
Inform your doctor if you have moderate to severe kidney disease.
Why is it important to keep my appointments with the doctor?
Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
- Certain tests to confirm if you have changes in your BRCA gene must be done to know if this medicine is suited for you to take.
- Pregnancy test must also be done before you start your treatment with this medicine.
- Routine tests (e.g. complete blood count and kidney function), and regular monitoring of signs and symptoms of serious side effects may also be done while you are being treated with this medicine. Your doctor will advise you about how often you need to have these tests.
Talazoparib may cause tiredness or dizziness. If affected, do not drive or take part in any activity in which you need to be alert or need to see clearly.
Other side effects include any of the following: nausea, vomiting, diarrhoea, stomach pain, indigestion, decreased appetite, headache, and hair loss.
This medicine will cause the level of your red blood cells, white blood cells and platelets to drop.
Red blood cells carry oxygen around your body. A fall in the level of red blood cells may make you feel tired and worn out.
White blood cells help your body to fight infections. A fall in the level of your white blood cells may put you at higher risk for infections, such as coughs, colds and flu, which may lead to more serious infections. Avoid crowded places and people who are sick. Alert your doctor if you have a fever, cough, or flu that does not go away.
Platelets help your blood to clot when there is a cut in the skin. A fall in the level of your platelets may put you at risk of bleeding more than usual. Do not take part in activities where you may fall or get injured, such as contact sports. Alert your doctor if you get any unusual bruising (large bruises or several bruises, especially if the bruises appeared on their own) or bleeding that takes a long time to stop (for example, too much bleeding when you floss or brush your teeth).
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Inform your doctor and pharmacist if you are taking any of these medicines:
- itraconazole (medicine for fungal infection)
- amiodarone (medicine for irregular heartbeat)
- medicines for high blood pressure e.g. carvedilol, verapamil
- clarithromycin (antibiotic)
This list does not include all medicines that may interact with Talazoparib.
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements, and medicines that you buy without a prescription.
Avoid alcohol.
Store in a cool, dry place away from the reach of children.
Medicines must not be used past the expiry date.
As Talazoparib is a cancer medicine, always return any unused or expired capsules to the clinic, hospital, or pharmacy for disposal. Do not throw it away in the household waste.
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