Sunolut Special Precautions

Because of occasional occurrence of thrombophlebitis and pulmonary embolism in patients taking progestogens, the physician should be alerted to the earliest manifestations of the disease. This drug may cause some degree of fluid retention, conditions which might be influenced by this factor, such as epilepsy, migraine, asthma, cardiac or renal dysfunction, require careful observation.
In cases of breakthrough bleeding, as in all cases of irregular bleeding per vaginam, non- functional causes should be borne in mind. In cases of undiagnosed vaginal bleeding, adequate diagnostic measures are indicated.
A decrease in glucose tolerance has been observed in a small percentage of patients on oestrogen-progestogen combination drugs. The mechanism of this decrease is obscure.
For this reason, diabetic patients should be carefully observed while receiving progestogen therapy. Steroid hormones are metabolized by the liver, therefore, these drugs should be administered with caution in patients with impaired liver function.