Hypersensitivity to the active ingredient or to any of the excipients according to the composition.
History of bronchospasms, urticaria or allergy-like symptoms after taking acetylsalicylic acid or other non-steroidal anti-inflammatory drugs.
History of gastrointestinal haemorrhage or perforation after taking other non-steroidal anti-inflammatory drugs.
Third trimester of pregnancy (see Use in Pregnancy & Lactation).
Active gastric and/or duodenal ulcers or gastrointestinal haemorrhage.
Inflammatory bowel disease (such as Crohn's disease, colitis ulcerosa).
Cerebrovascular bleeding.
Hemorrhagic diathesis.
Severe hepatic impairment (cirrhosis and ascites).
Severe kidney insufficiency (creatinine clearance <30 ml/min).
Severe heart failure (NYHA III-IV).
Treatment of postoperative pain following coronary bypass surgery (incl. use of a heart-lung machine)