Hypersensitivity to the active substance(s) or to any of the excipients listed in Description.
Hypersensitivity to sulphonamides (see Precautions).
Patients receiving monoamine oxidase (MAO) inhibitor therapy (see Interactions).
Patients on antidepressants which affect noradrenergic transmission (e.g. tricyclic antidepressants and mianserin) (see Interactions).
Patients with severe renal impairment (see Precautions).
Patients with hyperchloraemic acidosis.
Neonates and infants under the age of 2 years (see Precautions).