Sifrol Drug Interactions

Pramipexole is bound to plasma proteins to a very low (< 20 %) extent and little biotransformation is seen in man. Therefore, interactions with other medications affecting plasma protein binding or elimination by biotransformation are unlikely.
Medication that inhibit the active renal tubular secretion of basic (cationic) drugs, such as cimetidine, or are themselves eliminated by active renal tubular secretion, may interact with Sifrol resulting in reduced clearance of either or both medication. In case of concomitant treatment with these kind of drugs (including amantadine) attention should be paid to signs of dopamine overstimulation, such as dyskinesias, agitation or hallucinations. In such cases a dose reduction is necessary.
Selegiline and levodopa do not influence the pharmacokinetics of pramipexole. The overall extent of absorption or elimination of levodopa is not changed by pramipexole. The interaction with anticholinergics and amantadine has not been examined. As anticholinergics are mainly eliminated by hepatic metabolism, pharmacokinetic drug-drug interactions with pramipexole are rather unlikely. With amantadine, an interaction is possible via the same system of excretion in the kidney.
Antipsychotic medicinal products: Co-administration of antipsychotic medicinal products with pramipexole is not recommended, e.g. if dopamine-antagonistic effects can be expected. (see Warnings and Precautions).
While increasing the dose of Sifrol in Parkinson's disease patients it is recommended that the dosage of levodopa is reduced and the dosage of other anti-parkinsonian medication kept constant.
Because of possible additive effects, caution should be advised when patients are taking other sedating medications or alcohol in combination with Sifrol and when taking concomitant medications that increase plasma levels of pramipexole (e.g., cimetidine).