Salofalk Drug Interactions

There is weak evidence that mesalazine might decrease the anticoagulant effect of warfarin.
Tablet/Enema: Specific interaction studies have not been performed.
In patients who are concomitantly treated with azathioprine, 6-mercaptopurine or thioguanine, a possible increase in the myelosuppressive effects of azathioprine, 6-mercaptopurine or thioguanine should be taken into account.
Granules: Specific interaction studies have not been performed.
Lactulose or similar preparations which lower stool pH: possible reduction of mesalazine release from granules due to decreased pH caused by bacterial metabolism.
In patients who are concomitantly treated with azathioprine, 6-mercaptopurine or thioguanine, a possible increase in the myelosuppressive effects of azathioprine, 6-mercaptopurine or thioguanine should be taken into account.
Suppository: Interactions may occur if the following drugs are given at the same time as Salofalk: Anticoagulants: possible potentiation of the anticoagulative action (increased risk of bleeding in the gastrointestinal tract).
Glucocorticoids: possible increase in gastric side effects.
Sulphonylureas: possible potentiation of the hypoglycaemic effect.
Methotrexate: possible increase of the methotrexate toxicity.
Probenicid/sulphinpyrazone: possible reduction in uricosuric effects.
Spironolactone/furosemide: possible reduction in diuretic effects.
Rifampicin: possible reduction in tuberculostatic effects.