Rowatinex Mechanism of Action

Pharmacology: Pharmacodynamics: Rowatinex promotes diuresis and relaxes urinary tract spasm, thus assisting the passage of stones. The therapeutic effect of the balanced combination of terpenes reduces urinary tract inflammation stimulating renal blood flow through the kidneys and increasing the output of a less concentrated urine.
Pharmacokinetics: The absorption, distribution, metabolism and excretion were partially analysed for some of the terpenes contained in ROWATINEX (i.e. for α-pinene, β-pinene, camphene, cineol, borneol, anethol).
The most important conclusions with respect to the common properties of the single terpenes are that these compounds were rapidly absorbed after oral administration and undergo the first pass metabolism in the liver. Predominantly, terpenes are metabolized via ω-oxidation, O-demethylation and epoxidation pathways and are subsequently conjugated with glucuronic acid. The metabolized terpenes are rapidly eliminated mainly with the urine but partially also by the faeces and via exhalation. The metabolism involving the cytochrome P450 pathways and cytochrome P450 modulating activities of some terpenes may account for possible interactions with other drugs and in case of critical doses and the lacking of interaction studies with ROWATINEX special caution should be advised, despite the missing positive data.