The skin of certain sensitive individuals may become excessively red, edematous, blistered or crusted. If these effects occur, the medication should either be discontinued until the integrity of the skin is restored, or the medication should be adjusted to a level the patient can tolerate. True contact allergy to topical tretinoin is rarely encountered. Temporary hyper or hypopigmentation has been reported with repeated application of topical tretinoin. Some individuals have been reported to have heightened susceptibility to sunlight while under treatment with topical tretinoin. To date, all adverse effects to topical tretinoin have been reversible upon discontinuation of therapy (see DOSAGE & ADMINISTRATION).