Not for protection against HIV infections & other STD. Increased risk of VTE or ATE; +ve family history of VTE or ATE, obesity (BMI >30 kg/m
2), increasing age (>35 yr), smoking, cancer, SLE, haemolytic uraemic syndrome, Crohn's disease or ulcerative colitis, sickle cell disease; HTN, migraine, DM, hyperhomocysteinaemia, valvular heart disease, atrial fibrillation, dyslipoproteinaemia; breast cancer; benign or malignant liver tumours. Depression; hypertriglyceridaemia, pancreatitis; glucose intolerance/diabetes; GI disturbances; irregular bleeding. Prolonged immobilisation, major surgery or trauma, any leg or pelvis surgery. May induce or exacerbate symptoms of angioedema. Recurrence of cholestatic jaundice. Chloasma; avoid exposure to sun or UV radiation. Perform medical & physical exam including BP measurement prior to therapy. Not to be used w/ St. John's wort. Concomitant use of ombitasvir/paritaprevir/ritonavir & dasabuvir w/ or w/o ribavirin; glecaprevir/pibrentasvir. Not to be taken by patients w/ galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Acute or chronic hepatic function disturbances. Not indicated during pregnancy. Not recommended during lactation.