Prophylaxis of organ rejection in patients receiving allogeneic renal, cardiac & hepatic transplants in combination w/ cyclosporine & corticosteroids. Induction & maintenance treatment of lupus nephritis in combination w/ corticosteroids.
View Refrat overdosage for action to be taken in the event of an overdose.
Administration
Cap: Should be taken on an empty stomach: Do not open/crush. FC tab: May be taken with or without food: Swallow whole, do not crush/open. In stable renal transplant patients, may be administered w/ meals if necessary.
Contraindications
Hypersensitivity to mycophenolate mofetil, mycophenolic acid.
Increased risk of lymphomas & other malignancies. Bone marrow depression; active digestive system disease. Immunosuppressed patients. Post-transplant patients w/ delayed renal graft function. Monitor CBC & neutrophil during therapy. Avoid use in patients w/ hereditary deficiency of hypoxanthine-guanine phosphoribosyl-transferase eg, Lesch-Nyhan & Kelley-Seegmiller syndrome. Avoid sunlight & UV exposure. Not to be used w/ azathioprine. Avoid use of live attenuated vaccines. Concomitant use w/ drugs interfering enterohepatic circulation. Avoid doses >1 g in patients w/ severe chronic renal impairment. Women of childbearing potential should use effective contraception prior to, during & for 6 wk after treatment. Avoid use during pregnancy. Lactation. Paed patients. Elderly.
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