Moderate to severe atopic dermatitis in adults & childn who are not adequately responsive to or are intolerant of conventional therapies eg, topical corticosteroids. Moderate to severe atopic dermatitis for prevention of flares & prolongation of flare-free intervals in patients who have had initial response to max 6 wk of tacrolimus oint bd treatment experiencing high frequency of disease exacerbations ie, occurring ≥4 yrly.
Flare treatment Adult & adolescent ≥16 yr Apply 0.1% oint thinly to affected area bd until lesion clearance, reduce frequency or use 0.03% oint if clinical condition allows. Restart bd treatment w/ 0.1% oint if symptoms recur. Childn ≥2 yr Apply 0.03% oint thinly to affected area bd for up to 3 wk, reduce to once daily until lesion clearance. Maintenance treatment Adult & adolescent ≥16 yr Apply 0.1% oint thinly to affected area once daily twice wkly w/ 2-3 days interval. Childn ≥2 yr Apply 0.03% oint thinly to affected area once daily twice wkly w/ 2-3 days interval.
Discontinue use in presence of acute infectious mononucleosis. Not to be used in patients w/ congenital or acquired immunodeficiencies or on immunosuppression therapy. Not to be applied to potentially malignant or pre-malignant lesions. Not recommended in patients w/ skin barrier defects eg, Netherton's syndrome, lamellar icthyosis, generalized erythroderma or cutaneous Graft Versus Host Disease. Increased risk of folliculitis & herpes viral infections [herpes simplex dermatitis (eczema herpeticum),
herpes simplex (cold sores), Kaposi’s varicelliform eruption]. Clinically infected atopic dermatitis. Monitor patients who develop lymphadenopathy. Limit exposure to sunlight & avoid use of UV light from solarium; therapy w/ UVB or UVA in combination w/ psoralens (PUVA). Avoid contact w/ eyes & mucous membranes. Not to be applied under occlusive dressings. Prolonged & extensive use especially in childn. Not to be applied on same area w/ emollients w/in 2 hr. Increased risk of developing lymphomas & skin malignancies in transplant patients. Hepatic failure. Not to be used during pregnancy. Not recommended during lactation. Not to be used in childn <2 yr.
Sign Out
