View Premarin overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food: Swallow whole, do not divide/chew/crush or dissolve tab in mouth.
Contraindications
Hypersensitivity. Known or suspected estrogen-dependent neoplasia & breast cancer, thrombophilic disorders; undiagnosed abnormal uterine bleeding; active or history of confirmed arterial thromboembolic or venous thromboembolic disorders. Active or chronic hepatic dysfunction or disease. Known or suspected pregnancy.
Not to be initiated or continued to prevent CHD. Increased risk of MI, pulmonary embolism, invasive breast & ovarian cancer; CV risk, stroke, VTE; endometrial, breast & ovarian cancer; dementia; gallbladder disease; hypercalcemia; angioedema; fluid retention, cardiac dysfunction; preexisting hypertriglyceridemia; elevated BP; exacerbation of asthma, epilepsy, migraine w/ or w/o aura, otosclerosis, porphyria, SLE, hepatic hemangiomas, endometriosis; hypocalcemia, hypothyroidism; impaired glucose tolerance. Palliative therapy in men. History of cholestatic jaundice; hepatic impairment. Renal dysfunction. Not to be used during pregnancy & lactation. Childn. Elderly >65 yr.
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