Generic Medicine Info
Indications and Dosage
Corticosteroid-responsive dermatoses
Adult: As 0.1% cream or ointment: Apply a thin film and rub gently onto the affected area(s) bid. Discontinue therapy when control is achieved; reassess treatment if there is no improvement within 2 weeks. As 0.25% cream: Apply thinly onto affected area(s) 1-2 times daily.
Child: As 0.1% cream: ≥1 year Apply a thin film and rub gently onto the affected area(s) bid. Max treatment duration: 3 weeks. As 0.1% ointment: ≥10 years Same as adult.
As 0.25% cream: Skin manifestations resulting from chickenpox, syphilis, TB, vaccinations, or perioral dermatitis.
Special Precautions
Avoid application on the face, groin area, underarms or open wounds. Do not cover with occlusive dressings. Avoid contact with eyes; latex-containing products (e.g. condoms, diaphragm). Do not apply intravaginally. Children. Pregnancy and lactation.
Adverse Reactions
Significant: Hypercortisolism or HPA axis suppression (particularly at high doses for prolonged periods or in younger children), allergic contact dermatitis, fungal or bacterial superinfection, Kaposi sarcoma (prolonged use), hyperglycaemia or glycosuria.
Skin and subcutaneous tissue disorders: Burning, pruritus, drying, scaling, cracking, pain, irritant dermatitis, skin atrophy, urticaria, rash, oedema, paraesthesia.
Monitoring Parameters
Monitor growth (in children). If HPA axis suppression is suspected, evaluate patient using the ACTH stimulation, plasma cortisol, or urinary free cortisol test.
Mechanism of Action: Prednicarbate is a synthetic, nonhalogenated, medium-potency topical corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties. The exact mechanism for its anti-inflammatory activity is unclear; however, corticosteroids are thought to depress the formation, release, and activity of endogenous chemical mediators of inflammation such as kinins, histamine, liposomal enzymes, and prostaglandins through induction of phospholipase A2 inhibitory proteins (collectively called lipocortins) and sequential inhibition of the release of arachidonic acid.
Absorption: Absorbed percutaneously.
Chemical Structure

Chemical Structure Image

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 6714002, Prednicarbate. Accessed Feb. 27, 2023.

Cream: Store between 5-25°C. Ointment: Store between 20-25°C.
MIMS Class
Topical Corticosteroids
ATC Classification
D07AC18 - prednicarbate ; Belongs to the class of potent (group III) corticosteroids. Used in the treatment of dermatological diseases.
Anon. Prednicarbate. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. Accessed 22/12/2022.

Anon. Prednicarbate. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. Accessed 22/12/2022.

Buckingham R (ed). Prednicarbate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. Accessed 22/12/2022.

Dermatop (Sanofi‐Aventis). MIMS Thailand. Accessed 22/12/2022.

Dermatop Emollient Cream (Dermik Laboratories). U.S. FDA. Accessed 22/12/2022.

Dermatop Ointment (Dermik Laboratories). U.S. FDA. Accessed 22/12/2022.

Prednicarbate Ointment (Fougera Pharmaceuticals Inc.). DailyMed. Source: U.S. National Library of Medicine. Accessed 22/12/2022.

Disclaimer: This information is independently developed by MIMS based on Prednicarbate from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2024 MIMS. All rights reserved. Powered by
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