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Galcanezumab is a humanized IgG4 monoclonal antibody specific for calcitonin-gene related peptide (CGRP) ligand. Galcanezumab is produced in Chinese Hamster Ovary (CHO) cells by recombinant DNA technology. Galcanezumab is composed of two identical immunoglobulin kappa light chains and two identical immunoglobulin gamma heavy chains and has an overall molecular weight of approximately 147 kDa.
PONTEVIA (galcanezumab) injection is a sterile, preservative-free, clear to opalescent and colorless to slightly yellow to slightly brown solution, for subcutaneous use. PONTEVIA is supplied in a 1 mL single-dose prefilled pen to deliver 120 mg of galcanezumab. Each mL of solution contains 120 mg of galcanezumab; L-histidine (0.5 mg); L- histidine hydrochloride monohydrate (1.5 mg); Polysorbate 80 (0.5 mg); Sodium Chloride (8.8 mg); Water for Injection, USP. The pH range is 5.3 - 6.3.
