Adult: As 0.5% gel: Apply bid for 3 days; if needed, repeat at weekly intervals for 4 or 5 weeks treatment. Max: 0.5 g daily or ≤10 cm2 of wart tissue. Child: >12 years Same as adult dose.
Topical/Cutaneous Condyloma acuminata
Adult: For cases affecting the external genitals: As 0.15% cream or 0.5 % solution: Apply bid for 3 days; if needed, repeat at weekly intervals for 4 weeks. Max (0.5% solution): 0.5 mL daily or ≤10 cm2 of wart tissue.
Broken skin. Children <12 years. Pregnancy and lactation.
Significant: Application site reactions (e.g. irritation, inflammation, burning sensation, erythema, pruritus, bleeding), erosion. GI disorders: Vomiting. Nervous system disorders: Headache, dizziness. Psychiatric disorders: Insomnia. Renal and urinary disorders: Haematuria. Reproductive system and breast disorders: Balanoposthitis. Vascular disorders: Bleeding.
Avoid use of occlusive dressing or wrappings. Avoid contact with eyes and mucous membranes (e.g. genital area). Topical gel and solution is flammable, avoid exposure to excessive heat and flame. Refrain from engaging in sexual activity on days during treatment.
Symptoms: Nausea, vomiting, abdominal pain, diarrhoea, hepatotoxicity, renal failure, thrombocytopenia, leucopenia; delayed CNS-related effects including acute psychotic reactions, hallucinations, confusion, dizziness, stupor, ataxia, hypotonia, seizures, coma; delayed peripheral neuropathies resulting to paraesthesias, reduced reflexes, muscle weakness, tachycardia, apnoea, orthostatic hypotension, paralytic ileus, urinary retention. Management: Symptomatic and supportive treatment. Wash off from the application area.
Description: Mechanism of Action: Podophyllotoxin is a keratolytic with an antimitotic action. It binds to the microtubule protein of the mitotic spindle thereby inhibiting metaphase and leading to cell death and necrosis of wart tissue. Pharmacokinetics: Absorption: Absorbed through the skin or mucous membranes. Time to peak plasma concentration: 1-2 hour. Excretion: Plasma elimination half-life: 1- 4.5 hour.
Store between 20-25°C. Protect from excessive heat and open flames.
D06BB04 - podophyllotoxin ; Belongs to the class of topical antivirals used in the treatment of dermatological diseases.
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