Pentasa Dosage/Direction for Use

PR Tablet and PR Granules: Ulcerative colitis: Treatment of active disease: Adults: Individual dosage, up to 4 g given once daily or in divided doses.
Children 6 years of age and older: To be determined individually, starting with 30-50 mg/kg/day in divided doses. Maximum dose: 75 mg/kg/day in divided doses. The total dose should not exceed 4 g/day (maximum adult dose).
Maintenance treatment: Adults: Individual dosage. Recommended dosage, 1.5 g to 2 g mesalazine once daily in prolonged release tablets or 2 g mesalazine once daily in prolonged release granules. Can also be taken in divided doses.
Children 6 years of age and older: To be determined individually, starting with 15-30 mg/kg/day in divided doses. The total dose should not exceed 2 g/day (recommended adult dose).
Crohn's disease: Treatment of active disease: Adults: Individual dosage, up to 4 g daily in divided doses.
Children 6 years of age and older: To be determined individually, starting with 30-50 mg/kg/day in divided doses. Maximum dose: 75 mg/kg/day in divided doses. The total dose should not exceed 4 g/day (maximum adult dose).
Maintenance treatment: Adults: Individual dosage, up to 4 g daily in divided doses.
Children 6 years of age and older: To be determined individually, starting with 15-30 mg/kg/day in divided doses. The total dose should not exceed 4 g/day (recommended adult dose).
Note for paediatric population: There is only limited documentation for an effect in children (age 6-18 years).
It is generally recommended that half the adult dose may be given to children up to a body weight of 40 kg; and the normal adult dose to those above 40 kg.
Suppository and Enema: Paediatric population: There is little experience and only limited documentation for an effect in children.
Suppository: 1 suppository 1-2 times daily.
Enema: 1 enema at bedtime.
Method of Administration: PR Tablet: For oral use.
PENTASA tablets must not be chewed. To facilitate swallowing, the tablets may be dispersed in 50 ml of cold water. Stir and drink immediately.
PR Granules: For oral use.
PENTASA Sachet must not be chewed. The contents of the sachet should be emptied onto the tongue and washed down with some water or juice. Alternatively, the entire content of the sachet can be taken with yoghurt and consumed immediately.
Suppository and Enema: PENTASA Suppositories and Enema are for rectal administration.