Paliperidone - oral

Patient Medicine Information
Why do I need this medicine?
Paliperidone is used to treat schizophrenia (an illness that causes changes in perception, thoughts, and behaviour).

This medicine is also used on its own or together with other medicines to treat schizoaffective disorder (a mental illness that is marked by a combination of schizophrenia symptoms, such as hallucinations and delusions, and mood disorder symptoms, such as depression and feeling very high).

Paliperidone helps relieve symptoms common in schizophrenia and schizoaffective disorder, such as agitation, distorted thinking, and emotional instability.
How do I take this medicine?
Take Paliperidone exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

You may take this medicine with or without food. Try to take it at the same time each day.

This medicine is available as a prolonged-release or extended-release type of tablet, swallow it whole with a glass of water. Do not divide, chew, or crush the tablet.

The dose of this medicine will be decided by your doctor. Your doctor will advise you on the treatment timeframe depending on your condition and your response and tolerability to this medicine.

Paliperidone must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed by the doctor.
What should I do if I have forgotten to take this medicine?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.
When should I not use this medicine?
Do not take Paliperidone if you ever had an allergic reaction (e.g. rashes, breathlessness, swollen eyes) to this medicine or a similar medicine called risperidone.

Do not breastfeed while you are being treated with this medicine.
What should I take note of while taking this medicine?
Inform your doctor if you have the following conditions:
  • heart disease e.g. heart failure, history of heart attack, heart rhythm disorder
  • disease of the blood vessels supplying the brain
  • condition that may make you prone to low blood pressure
  • diabetes or prone to diabetes e.g. obesity, family history of diabetes
  • at risk for aspiration pneumonia (a lung infection that may occur when oral or stomach contents are breathed into the lungs or airways leading to the lungs instead of being swallowed)
  • history of fits or seizures
  • history of low white blood cell counts which may or may not have been caused by medicines
  • possible prolactin (hormone)-dependent tumour
  • Parkinson's disease (a disorder that affects the movement of a person, causing symptoms such as tremors, muscle stiffness, slowed movement, and impaired balance or walking)
  • kidney disease
  • severe liver disease
Let your doctor know if you are pregnant.

Be sure to check with your doctor or pharmacist before giving Paliperidone to a child or the elderly. Children and elderly people may be more sensitive to the side effects.

If you are going to have an eye operation for cataract (cloudiness of the lens), inform your doctor that you are taking this medicine.

You may see a small tablet-shaped casing in your bowel. This is normal, do not be alarmed. This casing is just an empty shell; the medicine inside it has already been absorbed by your body.

Why is it important to keep my appointments with the doctor?

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
  • Routine tests (e.g. complete blood count, kidney and liver function, electrolyte, blood sugar and cholesterol levels, eye examination) may be done while you are being treated with this medicine. Your doctor will advise you about how often you need to have these tests.
  • Your blood pressure may fall or rise to unsafe levels without you noticing it. Monitor your blood pressure before and during treatment.
  • Regular monitoring of weight, mental status, and abnormal movements of the tongue or face may also be needed.
What lifestyle changes should I make?

Paliperidone may affect the ability of your body to adjust to temperature changes in the environment. Avoid exposure to very cold or very hot environments. Avoid strenuous exercise and activities like going to the sauna. Drink more water to prevent dehydration.
What side effects could I experience?
Paliperidone may cause drowsiness, dizziness, or blurred vision. If affected, do not drive or take part in any activity in which you need to be alert or need to see clearly.

This medicine may cause your blood pressure to fall suddenly when you get up from a sitting or lying down position and you may feel giddy. To minimise this problem, stand up slowly.

Other side effects include any of the following: weight gain, headache, tremors, stomach pain or discomfort, nausea, vomiting, constipation, diarrhoea, indigestion, toothache, increased or decreased appetite, fever, fatigue, weakness, cough, nasal congestion, throat pain, muscle and joint pain, difficulty sleeping, and loss of menstrual period.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
  • rashes, breathlessness, swelling of the face, eyes, or mouth
  • fast or abnormal heartbeat
  • abnormally high temperature, muscle tension, excessive sweating, altered consciousness
  • uncontrollable twitching movements of the mouth, tongue, and limbs
  • frequent or persistent sore throat with fever
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Inform your doctor and pharmacist if you are taking any of these medicines:
  • medicines for irregular heartbeat e.g. quinidine, amiodarone, sotalol
  • other medicines for mood disorders e.g. risperidone, chlorpromazine, thioridazine
  • medicines for Parkinson's disease e.g. levodopa
  • medicines to treat fits or seizures e.g. carbamazepine, valproate semisodium
This list does not include all medicines that may interact with Paliperidone.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements, and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol. Alcohol intake may worsen the dizziness and drowsiness caused by Paliperidone.
How should I store this medicine?
Store in a cool, dry place away from the reach of children.

Protect from moisture.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on paliperidone - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2024 MIMS. All rights reserved. Powered by
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