Discontinue use if anaphylactic or other severe hypersensitivity/allergic reactions occur. Not to be inj via intraarterial or paravenous administration. Delay treatment in patients w/ unhealed open soft tissue mouth lesions. Avoid overhydration in patients at risk of cardiac failure. Osteonecrosis of the jaw & external auditory canal; atypical subtrochanteric & diaphyseal femoral fractures. Correct existing hypocalcemia prior to therapy. Ensure adequate intake of Ca & vit D. Perform dental exam w/ preventive dentistry prior to treatment. Avoid invasive dental procedures & maintain good oral hygiene during treatment. Long-term therapy. Not recommended in patients w/ serum creatinine >200 micromol/L (2.3 mg/dL) or CrCl <30 mL/min. Not to be taken by women of childbearing potential. Not to be used during pregnancy & lactation. Not to be used in childn <18 yr.
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